143491-57-0 Emtricitabine AKSci J11199
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  J11199    AKSci Reference Standard
, 99% (HPLC)

CAS Number:143491-57-0
MDL Number:MFCD00870151
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:149-154°C
Optical Rotation:-133±2 ° (c=0.23, MeOH)
Long-Term Storage:Store long-term at -20°C
Not hazardous material

Application(s):Nucleoside reverse transcriptase inhibitor (NRTI)
Form:Free Base


 Emtricitabine works by inhibiting reverse transcriptase, the enzyme that copies HIV RNA into new viral DNA. Emtricitabine is a synthetic nucleoside analogue of cytidine. It is phosphorylated by cellular enzymes to form emtricitabine 5''-triphosphate, which is responsible for the inhibition of HIV-1 reverse transcriptase. It competes with the natural substrate deoxycytidine 5''-triphosphate and incorporates into nascent viral DNA, resulting in early chain termination. Therefore emtricitabine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate deoxycytidine 5''-triphosphate and by its incorporation into viral DNA. By inhibiting HIV-1 reverse transcriptase, emtricitabine can help to lower the amount of HIV, or ''''viral load'''', in a patient''s body and can indirectly increase the number of immune system cells (called T cells or CD4+ T-cells). Both of these changes are associated with healthier immune systems and decreased likelihood of serious illness.

[1]Masho SW, Wang CL, Nixon DE: Review of tenofovir-emtricitabine. Ther Clin Risk Manag. 2007 Dec;3(6):1097-104.
[2] Long MC, King JR, Acosta EP: Pharmacologic aspects of new antiretroviral drugs. Curr HIV/AIDS Rep. 2009 Feb;6(1):43-50.
[3] Emtricitabine/tenofovir disoproxil fumarate. Drugs R D. 2004;5(3):160-1.
[4] Goicoechea M, Best B: Efavirenz/emtricitabine/tenofovir disoproxil fumarate fixed-dose combination: first-line therapy for all? Expert Opin Pharmacother. 2007 Feb;8(3):371-82.



Signal Word

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of July 13, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.

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 APIs and Bioactives > Antivirals, Antiretrovirals, NRTIs