104757-53-1 Barnidipine HCl AKSci J11157
 
 
Loading Please Wait...
  J11157    AKSci Reference Standard
Barnidipine HCl
, >98% (HPLC)
 



IDENTITY
CAS Number:104757-53-1
MDL Number:MFCD00915772
MF:C27H29N3O6.HCl
MW:529.00
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:225-232°C
Optical Rotation:+116 ~ +120° (c=1, MeOH)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Calcium channel blocker
Form:HCl salt

REVIEW

 Barnidipine hydrochloride is a chiral dihydropyridine calcium channel blocker used as an antihypertensive. It is an L-type CCB with high affinity for [3H]nitrendipine binding sites.

REFERENCES
[1]Tamazawa, Kazuharu; Arima, Hideki; Kojima, Tadao; Isomura, Yasuo; Okada, Minoru; Fujita, Shigeo; Furuya, Toshio; Takenaka, Toichi; Inagaki, Osamu; Terai, Michio Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Journal of Medicinal Chemistry (1986), 29(12), 2504-11.
[2] Arima, Hideki; Tamazawa, Kazuharu A process for the preparation of (4S)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid (3S)-3-(1-benzyl)-3-pyrrolidinyl) ester 5-methyl ester as a vasodilator and antihypertensive Jpn. Kokai Tokkyo Koho (1987), JP 62174071 A 19870730.
[3] Liau CS. Barnidipine: a new calcium channel blocker for hypertension treatment. Expert Rev Cardiovasc Ther. 2005 Mar;3(2):207-13.
[4] Malhotra HS, Plosker GL Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 1, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS Request COA

⚠️
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.


CATEGORIES

 APIs and Bioactives > Calcium Channel Blockers


PubChem