180200-66-2 Gatifloxacine sesquihydrate AKSci J11144
 
 
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  J11144    AKSci Reference Standard
Gatifloxacine sesquihydrate, 99% (HPLC), powder
 
(+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, sesquihydrate
IDENTITY
CAS Number:180200-66-2
MDL Number:MFCD22373645
MF:C19H22FN3O4·1.5(H2O)
MW:402.01 (384.47 anhy)
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:185-188°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Antibiotic; Bacterial enzymes DNA gyrase and topoisomerase IV inhibitor
Form:Hydrate

REVIEW
 An antibiotic of the fourth-generation fluoroquinolone family. The drug inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

REFERENCES
[1]Malik M, Chavda K, Zhao X, Shah N, Hussain S, Kurepina N, Kreiswirth BN, Kerns RJ, Drlica K (2012). Induction of mycobacterial resistance to quinolone class antimicrobials. Antimicrob Agents Chemother. 56(7):3879-87. PMID 22564842.
[2] Juárez-Verdayes MA, Parra-Ortega B, Hernández-Rodríguez C, Betanzos-Cabrera G, Rodríguez-Martínez S, Cancino-Diaz ME, Cancino-Diaz JC (2012). Identification and expression of nor efflux family genes in Staphylococcus epidermidis that act against gatifloxacin. Microb Pathog. 52(6):318-25. PMID 22426170.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H312; H332

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P312; P322; P330; P363; P501

RELATED PRODUCTS
X5018Gatifloxacin mesylate
F432Gatifloxacine sesquihydrate
O378Gatifloxacin hydrochloride

Current as of April 25, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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⚠️
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CATEGORIES
 APIs and Bioactives > Antibacterials, Quinolones


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