479-18-5 Dyphylline AKSci J11143
 
 
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  J11143    AKSci Reference Standard
Dyphylline
, 99% (HPLC)
 
7-(2,3-Dihydroxypropyl)theophylline
Dilor
Diprophylline
more..




IDENTITY
CAS Number:479-18-5
MDL Number:MFCD00005759
MF:C10H14N4O4
MW:254.24
EINECS:207-526-1
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Spectra:NMR, LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:160-166°C
Long-Term Storage:Store at room temperature
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 51mg/mL; H2O: 50mg/mL; EtOH: <1mg/mL
Application(s):Bronchodilator Agent; Phosphodiesterase Inhibitor; Vasodilator Agent
Form:Free Base

REVIEW

 A xanthine derivative with bronchodilator and vasodilator effects. It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor.

REFERENCES
[1]Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD (2010). Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. J Med Chem. 53(3):1098-108. PMID 20070106.
[2] Dorfmueller HC, van Aalten DM (2010). Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds. FEBS Lett. 584(4):694-700. PMID 20026047.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of September 27, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 Heterocyclic Building Blocks > Purines
 Nucleobases > Purines
 Nucleobases > Purines


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