51898-34-1 Vitamin E nicotinate AKSci J11035
 
 
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  J11035    AKSci Reference Standard
Vitamin E nicotinate
, >99% (HPLC)
 
(±)-α-Tocopherol nicotinate




IDENTITY
CAS Number:51898-34-1
MDL Number:MFCD03548047
MF:C35H53NO3
MW:535.8
EINECS:257-501-4
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>99% (HPLC)
Spectra:LCMS, FT-IR, HPLC
Physical Form:Off-white to light yellow crystalline powder
Melting Point:47-53°C
Long-Term Storage:Store long-term at 2-8°C
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

REVIEW

 Tocopherol nicotinate is an ester of alpha-Tocopherol, which has vitamin E activity, and is the form of vitamin E that is preferentially absorbed and accumulated in humans. The main source found in supplements and in the European diet, where the main dietary sources are olive and sunflower oils, while gamma-tocopherol is the most common form in the American diet due to a higher intake of soybean and corn oil. Tocopheryl nicotinate is used in cosmetics as an antioxidant, skin conditioner and protecting agent, and some pharmaceuticals.

REFERENCES
[1]Vogel, F. G. M.; Sperling, K.; Pugliese, Peter T. Vitamin E nicotinate - a new active agent in cosmetics. Parfuemerie und Kosmetik. (1987) 68(9): 540, 543-4.
[2] Hata, Yoshiya; Matsuzaki, Toshihisa; Terashi, Akira; Ohtomo, Eichiro; Yoshida, Ryoichi; Ohni, Mitsuo; Yamamoto, Minoru; Kitamura, Shin; Nagazumi, Atsushi; Goto, Yuichiro. Secondary prevention of cerebrovascular disease with dL-a-tocopheryl nicotinate, Edited by Mino, Makoto. Vitam. E. (1993) 283-9.
[3] Zondlo Fiume M. Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan. Int J Toxicol. (2002) 21 Suppl 3: 51-116.
[4] Naumova, B. S.; Chekmareva, I. B.; Zhdanovich, E. S.; Preobrazhenskii, N. A.Preparation of nicotinic acid derivatives Khimiko-Farmatsevticheskii Zhurnal (1969), 3(5), 11-12.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of June 16, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Vitamins


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