2315-02-8 Oxymetazoline hydrochloride AKSci J11006

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J11006 AKSci Reference Standard
Oxymetazoline hydrochloride, >99% (HPLC)

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2-(3-Hydroxy-2,6-dimethyl-4-t-butylbenzyl)-2-imidazoline hydrochloride

IDENTITY
CAS Number:	2315-02-8
MDL Number:	MFCD00058147
MF:	C16H25ClN2O
MW:	296.84

SPECIFICATIONS & PROPERTIES
Purity:	>99% (HPLC)
Spectra:	NMR, LCMS, FT-IR, HPLC
Physical Form:	White to off-white crystalline powder
Melting Point:	>300°C
Long-Term Storage:	Store at room temperature
UN #:	UN2811
Hazard Class:	6.1
Packing Group:	I

BIOLOGICAL INFO
Solubility:	DMSO: 59mg/mL; H2O: 50mg/mL; EtOH: 59mg/mL
Application(s):	Adrenergic Receptor agonist
Form:	HCl salt

REVIEW
Oxymetazoline is a direct acting sympathomimetic amine, which acts on alpha-adrenergic receptors in the arterioles of the conjunctiva and nasal mucosa. It produces vasoconstriction, resulting in decreased conjunctival congestion in ophthalmic. In nasal it produces constriction, resulting in decreased blood flow and decreased nasal congestion.

REFERENCES

[1]	Katz, R.I. et al. (1990). A comparison of cocaine, lidocaine with epinephrine, and oxymetazoline for prevention of epistaxis on nasotracheal intubation. J Clin Anesth 2 (1): 16-20. doi:10.1016/0952-8180(90)90043-3. PMID 2310576.
[2]	Krempl, G.A. and A.D. Noorily (1995). Use of oxymetazoline in the management of epistaxis. Ann Otol Rhinol Laryngol 104 (9 Pt 1): 704-6. PMID 7661519.
[3]	J. Widdicombe (1997). Microvascular anatomy of the nose. Allergy 52 (40 Suppl): 7-11. doi:10.1111/j.1398-9995.1997.tb04877.x. PMID 9353554.
[4]	JT Ramey, E Bailen, RF Lockey (2006). Rhinitis medicamentosa. J Investig Allergol Clin Immunol 16 (3): 148-155. PMID 16784007.