132-17-2 Benztropine mesylate AKSci J10974
 
 
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  J10974    AKSci Reference Standard
Benztropine mesylate, 99% (HPLC)
 



IDENTITY
CAS Number:132-17-2
MDL Number:MFCD00074784
MF:C21H25NO.CH4O3S
MW:403.54
EINECS:205-048-8
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White to off-white powder
Melting Point:133-135°C
Long-Term Storage:Store long-term at 2-8°C
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III

BIOLOGICAL INFO
Solubility:Soluble in water
Application(s):Dopamine transporter (DAT) inhibitor

REVIEW
 Benztropine is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Benztropine partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.

REFERENCES
[1]Wszola BA, Newell KM, Sprague RL: Risk factors for tardive dyskinesia in a large population of youths and adults. Exp Clin Psychopharmacol. 2001 Aug;9(3):285-96.
[2] van Harten PN, Hoek HW, Matroos GE, Koeter M, Kahn RS: Intermittent neuroleptic treatment and risk for tardive dyskinesia: Curacao Extrapyramidal Syndromes Study III. Am J Psychiatry. 1998 Apr;155(4):565-7.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301+H311+H331

Precautionary Statements
P261; P264; P270; P271; P280; P301+P310; P302+P352; P304+P340; P312; P322; P330; P361; P363; P403+P233; P405; P501

Current as of July 3, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > AChR Antagonists


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