152-11-4 (+/-)-Verapamil hydrochloride AKSci J10969
 
 
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  J10969    AKSci Reference Standard
(+/-)-Verapamil hydrochloride
, 99% (HPLC), powder
 



IDENTITY
CAS Number:152-11-4
MDL Number:MFCD00055208
MF:C27H39ClN2O4
MW:491.06
EINECS:205-800-5
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:140-144°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply, depending on the amount ordered.

BIOLOGICAL INFO
Application(s):Class IV anti-arrhythmia agent

REVIEW

 Verapamil is a phenylalkylamine L-type calcium channel blocker. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and, more recently, cluster headaches and is also an effective preventive medication for migraine. Verapamil has also been used as a vasodilator during cryopreservation of blood vessels. Verapamil's mechanism in all cases is to block voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thus reducing heart rate and blood pressure.

REFERENCES
[1]Basic substituted phenylacetonitriles Belg. (1962), BE 615861 A1 19621001.
[2] Appel, Walter alpha-Isopropyl-alpha-[gamma-(N-methyl-N-homoveratrylamino)propyl]-alpha-(3,4-dimethoxyphenyl)acetonitrile, its determination in biological material and its activity in blood Arzneimittel-Forschung (1962), 12, 562.
[3] Dengel, Ferdinand Method for preparation of basically substituted phenylacetonitriles Ger. (1963), DE 1154810 B 19630926.
[4] Guerrero JR, Martin SS.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301+H311+H331

Precautionary Statements
P261; P264; P270; P271; P280; P301+P310; P302+P352; P304+P340; P312; P322; P330; P361; P363; P403+P233; P405; P501


Current as of September 29, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Arrhythmia, Calcium Channel Blockers


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