1508-75-4 Tropicamide AKSci J10912

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J10912 AKSci Reference Standard
Tropicamide, 99% (HPLC)

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N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide

IDENTITY
CAS Number:	1508-75-4
MDL Number:	MFCD00058580
MF:	C17H20N2O2
MW:	284.35
EINECS:	216-140-2

SPECIFICATIONS & PROPERTIES
Purity:	99% (HPLC)
Spectra:	LCMS, HPLC
Physical Form:	White crystalline powder
Melting Point:	96-97°C
Long-Term Storage:	Store at room temperature

BIOLOGICAL INFO
Application(s):	Anticholinergic and a muscarinic receptor subtype M4-preferring antagonist

REVIEW
Tropicamide binds to and blocks the receptors in the muscles of the eye (muscarinic receptor M4). Tropicamide acts by blocking the responses of the iris sphincter muscle to the iris and ciliary muscles to cholinergic stimulation, producing dilation of the pupil and paralysis of the ciliary muscle.

REFERENCES

[1]

Manny RE, Hussein M, Scheiman M, Kurtz D, Niemann K, Zinzer K (July 2001). Tropicamide (1%): an effective cycloplegic agent for myopic children. Investigative Ophthalmology & Visual Science 42 (8): 1728-35. PMID 11431435.

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