REVIEW Lansoprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but rather suppress gastric acid secretion by specific inhibition of the (H+,K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the parietal cell, Lansoprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.
Effects on 24-Hour Intragastric pHFreston M.D., Ph.D., James; Yi-Lin Chiu, Ph.D., Wei-Jian Pan, Ph.D., Nancy Lukasik, B.S.N., and Jörg Täubel, M.D., A.F.P.M. (2001). Effects on 24-Hour Intragastric pH: A Comparison of Lansoprazole Administered Nasogastrically in Apple Juice and Pantoprazole Administered Intravenously. American Journal of Gastroenterology 96 (7): 2058-2065. doi:10.1111/j.1572-0241.2001.03939.x. ISSN 0002-9270. OCLC 440925790. PMID 11467632.
Herzig SJ, Howell MD, Ngo LH, Marcantonio ER (May 2009). Acid-suppressive medication use and the risk for hospital-acquired pneumonia. JAMA 301 (20): 2120-8. doi:10.1001/jama.2009.722. PMID 19470989.
Pali-Schöll I, Jensen-Jarolim E (April 2011). Anti-acid medication as a risk factor for food allergy. Allergy 66 (4): 469-77. doi:10.1111/j.1398-9995.2010.02511.x. PMID 21121928.
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