103577-45-3 Lansoprazole AKSci J10874
 
 
Loading Please Wait...
  J10874    
Lansoprazole, >98% (HPLC), powder
 
Bamalite
Monolitum
Agopton
more..
IDENTITY
CAS Number:103577-45-3
MDL Number:MFCD00866873
MF:C16H14F3N3O2S
MW:369.36
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:173-182°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 74mg/mL; H2O: <1mg/mL; EtOH: 14mg/mL
Application(s):Proton-pump inhibitor (PPI); Enzyme Inhibitor
Form:Free Base

REVIEW
 Lansoprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but rather suppress gastric acid secretion by specific inhibition of the (H+,K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the parietal cell, Lansoprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.

REFERENCES
[1]Effects on 24-Hour Intragastric pHFreston M.D., Ph.D., James; Yi-Lin Chiu, Ph.D., Wei-Jian Pan, Ph.D., Nancy Lukasik, B.S.N., and Jörg Täubel, M.D., A.F.P.M. (2001). Effects on 24-Hour Intragastric pH: A Comparison of Lansoprazole Administered Nasogastrically in Apple Juice and Pantoprazole Administered Intravenously. American Journal of Gastroenterology 96 (7): 2058-2065. doi:10.1111/j.1572-0241.2001.03939.x. ISSN 0002-9270. OCLC 440925790. PMID 11467632.
[2] Herzig SJ, Howell MD, Ngo LH, Marcantonio ER (May 2009). Acid-suppressive medication use and the risk for hospital-acquired pneumonia. JAMA 301 (20): 2120-8. doi:10.1001/jama.2009.722. PMID 19470989.
[3] Pali-Schöll I, Jensen-Jarolim E (April 2011). Anti-acid medication as a risk factor for food allergy. Allergy 66 (4): 469-77. doi:10.1111/j.1398-9995.2010.02511.x. PMID 21121928.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
G437Lansoprazole
W0028Dexlansoprazole

Current as of April 19, 2024


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Proton Pump Inhibitors


PubChem