120011-70-3, 142057-77-0; 64-17-5; 120014-06-4; 110119-84-1 Donepezil HCl AKSci J10827
 
 
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  J10827    AKSci Reference Standard
Donepezil HCl, 99% (HPLC), powder
 
2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone hydrochloride
Aricept
IDENTITY
CAS Number:120011-70-3, 142057-77-0; 64-17-5; 120014-06-4; 110119-84-1
MDL Number:MFCD00881312
MF:C24H30ClNO3
MW:415.95
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:223-227°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 1mg/mL; H2O: 31mg/mL; EtOH: 2mg/mL
Application(s):AChE inhibitor; bAChE; hAChE
Form:HCl salt

REVIEW
 A centrally acting reversible acetylcholinesterase inhibitor. The main therapeutic use is in the palliative treatment of mild to moderate Alzheimer's disease.

REFERENCES
[1]Myhrer T, Enger S, Aas P (2010). Behavioral side effects in rats treated with acetylcholinesterase inhibitors suggested used as prophylactics against nerve agents. Pharmacol Biochem Behav. 95(3):338-43. PMID 20184916.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
I903Donepezil
G750Donepezil HCl

Current as of March 29, 2023

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > AChR Agonists, Alzheimer's


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