120011-70-3 Donepezil HCl AKSci J10827
 
 
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  J10827    
Donepezil HCl
, 99% (HPLC)
 
2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone hydrochloride
Aricept




IDENTITY
CAS Number:120011-70-3
MDL Number:MFCD00881312
MF:C24H30ClNO3
MW:415.95
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:LCMS, FT-IR, HPLC
Physical Form:White to off-white powder
Melting Point:223-227°C
Long-Term Storage:Store at room temperature
UN #:Not hazmat

BIOLOGICAL INFO
Solubility:DMSO: 1mg/mL; H2O: 31mg/mL; EtOH: 2mg/mL
Application(s):AChE inhibitor; bAChE; hAChE
Form:HCl salt

REVIEW

 A centrally acting reversible acetylcholinesterase inhibitor. The main therapeutic use is in the palliative treatment of mild to moderate Alzheimer's disease.

REFERENCES
[1]Myhrer T, Enger S, Aas P (2010). Behavioral side effects in rats treated with acetylcholinesterase inhibitors suggested used as prophylactics against nerve agents. Pharmacol Biochem Behav. 95(3):338-43. PMID 20184916.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
I903Donepezil
G750Donepezil HCl

Current as of January 18, 2019


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CATEGORIES

 APIs and Bioactives > AChR Agonists, Alzheimer's


PubChem