80-49-9 Homatropine methylbromide AKSci J10824
 
 
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  J10824    AKSci Reference Standard
Homatropine methylbromide
, >98% (HPLC)
 
N-Methylhomatropinium Bromide




IDENTITY
CAS Number:80-49-9
MDL Number:MFCD00050292
MF:C17H24BrNO3
MW:369.094
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Spectra:NMR, LCMS, HPLC
Physical Form:White to off-white to light yellow to yellow powder
Melting Point:191-203°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:Soluble in water and ethanol
Application(s):Quaternary ammonium muscarinic acetylcholine receptor antagonist

REVIEW

 Homatropine is a quaternary ammonium muscarinic acetylcholine receptor antagonist. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Homatropine methylbromide inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of March 25, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > AChR Antagonists


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