REVIEW Flucytosine penetrates into fungal cells and is converted to fluorouracil, an antimetabolite. By interfering with purine and pyrimidine uptake and by deaminated to 5-fluorouracil (5-FU) and then converted to 5-fluorodeoxyuridylic acid monophosphate, a noncompetitive inhibitor of thymidylate synthetase which interferes with DNA synthesis. , flucytosine interrupts nucleic acid and protein synthesis. The cells of the host do not convert large quantities of flucytosine to fluorouracil, accounting for the selective toxicity of the compound against fungi.
REFERENCES
[1]
Product Information: Ancobon® (flucytosine), ICN, Costa Mesa, CA, rev. 12/96, reviewed 2/2000.
[2]
Diasio RB, Bennett JE & Myers CE: Mode of action of 5-fluorocytosine. Biochem Pharmacol 1978; 27:703.
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