4759-48-2 Isotretinoin AKSci J10790
 
 
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  J10790    AKSci Reference Standard
Isotretinoin
, >98% (HPLC), powder
 
13-cis-Retinoic acid
Accutane
Amnesteem
more..




IDENTITY
CAS Number:4759-48-2
MDL Number:MFCD00079542
MF:C20H28O2
MW:300.44
EINECS:225-296-0
BRN:1885770
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Spectra:NMR,LCMS, FT-IR, HPLC, ROI
Physical Form:Yellow to orange to yellow-orange powder or crystalline powder
Melting Point:172-177°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 60mg/mL; H2O: <1mg/mL; EtOH: 8mg/mL; CHCl3: 50mg/mL
Application(s):Hydroxylase inhibitor
Form:Free Base

REVIEW

 Isotretinoin noticeably reduces the production of sebum and shrinks the sebaceous glands. It stabilises keratinization and prevents comedones from forming. It also reduces inflammation in moderate-severe inflammatory acne. The exact mechanism of action is unknown, however it is known that it alters DNA transcription.

REFERENCES
[1]Berard A, Azoulay L, Koren G, Blais L, Perreault S, Oraichi D: Isotretinoin, pregnancies, abortions and birth defects: a population-based perspective. Br J Clin Pharmacol. 2007 Feb;63(2):196-205.
[2] Holmes SC, Bankowska U, Mackie RM: The prescription of isotretinoin to women: is every precaution taken? Br J Dermatol. 1998 Mar;138(3):450-5.
[3] Amichai B, Shemer A, Grunwald MH: Low-dose isotretinoin in the treatment of acne vulgaris. J Am Acad Dermatol. 2006 Apr;54(4):644-6.
[4] Seukeran DC, Cunliffe WJ: Acne vulgaris in the elderly: the response to low-dose isotretinoin. Br J Dermatol. 1998 Jul;139(1):99-101.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H315; H319; H335; H360

Precautionary Statements
P201; P202; P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P308+P313; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of September 20, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Dermatology


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