REVIEW Cefquinome is a fourth-generation cephalosporin beta-lactam with pharmacological and antibacterial properties valuable in the treatment of coliform mastitis and other infections. It is only used in veterinary applications (cows, horse, pigs, and fowl). Cefquinome is resistant to beta-lactamase. Its zwitterionic structure can facilitate rapid penetration across biological membranes, including pores of bacterial cell wall. Plus, it has a higher affinity to target penicillin binding proteins. Cefquinome acts by inhibition of the cell wall synthesis, but it has a relatively short half-life of about two and half hours. It is less than 5% protein bound and is excreted unchanged in the urine.
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