16595-80-5 Levamisole HCl AKSci J10788
 
 
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  J10788    AKSci Reference Standard
Levamisole HCl, 99% (HPLC)
 
(-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride
(-)-Tetramisole hydrochloride
(S)-(-)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride
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IDENTITY
CAS Number:16595-80-5
MDL Number:MFCD00012675
MF:C11H12N2S.HCl
MW:240.75
EINECS:240-654-6
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:225-234°C
Optical Rotation:-130 - -122° (c=1, H2O)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: <1mg/mL; H2O: 48mg/mL; EtOH: <1mg/mL
Application(s):Alkaline phosphatase inhibitor
Form:HCl salt

REVIEW
 An anthelminthic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g. human liver, bone, kidney, and spleen) except the intestinal and placental isoform.[19] It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols.

REFERENCES
[1]Chang L, Duy do L, Mébarek S, Popowycz F, Pellet-Rostaing S, Lemaire M, Buchet R (2011). Synthesis and evaluation of thiophenyl derivatives as inhibitors of alkaline phosphatase. Bioorg Med Chem Lett. 21(8):2297-301. PMID 21421310.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501

Current as of April 16, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antiparasitics


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