153-61-7 Cephalothin AKSci J10773
 
 
Loading Please Wait...
  J10773    AKSci Reference Standard
Cephalothin, >98% (HPLC)
 
Cephalotin acid
IDENTITY
CAS Number:153-61-7
MDL Number:MFCD00242614
MF:C16H16N2O6S2
MW:396.44
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:167-169°C(dec)
Optical Rotation:50° (c=1.03, in acetonitrile)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Cefalothin is a first-generation cephalosporin beta-lactam antibiotic. It was the first cephalosporin marketed (1964) and continues to be widely used. It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. Cefalotin sodium is commonly marketed under the trade name Keflin (Lilly).. The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall component from being properly synthesized.

REFERENCES
[1]GODZESKI C W; BRIER G; PAVEY D E Cephalothin, a new cephalosporin with a broad antibacterial spectrum. I. In vitro studies employing the gradient plate technique Applied microbiology (1963), 11, 122-7.
[2] Comparative clinical pharmacology of intravenous cefoxitin and cephalothin Sonneville P F; Kartodirdjo R R; Skeggs H; Till A E; Martin C M European journal of clinical pharmacology (1976), 09(5-6), 397-403.
[3] Inhibition of synthesis of the cell wall of Staphylococcus aureus by cephalothin Chang, Te-Wen; Weinstein, Louis Science (Washington, DC, United States) (1964), 143(3608), 807-8.
[4] Newall, Christopher E.; Hallam, Paul D.Edited beta-Lactam antibiotics: penicillins and cephalosporins by Hansch, Corwin; Sammes, Peter G.; Taylor, John B Comprehensive Medicinal Chemistry (1990), 2, 609-653.
[5] Weinstein A J The cephalosporins: activity and clinical use Drugs (1980), 20(2), 137-54.
[6] Neu H C Comparative studies of cefoxitin and cephalothin: an overview Reviews of infectious diseases (1979), 1(1), 144-51.
[7] Perkins, R. L. Cephalothin and cephaloridine: comparative clinical and laboratory appraisal Internationale Zeitschrift fuer Klinische Pharmakologie, Therapie und Toxikologie (1968), 49-64.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of October 13, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Antibacterials, Cephalosporins


PubChem
  @PubMed