REVIEW Cefalothin is a first-generation cephalosporin beta-lactam antibiotic. It was the first cephalosporin marketed (1964) and continues to be widely used. It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. Cefalotin sodium is commonly marketed under the trade name Keflin (Lilly).. The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall component from being properly synthesized.
REFERENCES
[1]
GODZESKI C W; BRIER G; PAVEY D E Cephalothin, a new cephalosporin with a broad antibacterial spectrum. I. In vitro studies employing the gradient plate technique Applied microbiology (1963), 11, 122-7.
[2]
Comparative clinical pharmacology of intravenous cefoxitin and cephalothin Sonneville P F; Kartodirdjo R R; Skeggs H; Till A E; Martin C M European journal of clinical pharmacology (1976), 09(5-6), 397-403.
[3]
Inhibition of synthesis of the cell wall of Staphylococcus aureus by cephalothin Chang, Te-Wen; Weinstein, Louis Science (Washington, DC, United States) (1964), 143(3608), 807-8.
[4]
Newall, Christopher E.; Hallam, Paul D.Edited beta-Lactam antibiotics: penicillins and cephalosporins by Hansch, Corwin; Sammes, Peter G.; Taylor, John B Comprehensive Medicinal Chemistry (1990), 2, 609-653.
[5]
Weinstein A J The cephalosporins: activity and clinical use Drugs (1980), 20(2), 137-54.
[6]
Neu H C Comparative studies of cefoxitin and cephalothin: an overview Reviews of infectious diseases (1979), 1(1), 144-51.
[7]
Perkins, R. L. Cephalothin and cephaloridine: comparative clinical and laboratory appraisal Internationale Zeitschrift fuer Klinische Pharmakologie, Therapie und Toxikologie (1968), 49-64.
All products are stocked and shipped from San Francisco Bay Area, California, USA.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
