52-01-7 Spironolactone AKSci J10751
 
 
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  J10751    AKSci Reference Standard
Spironolactone
, 99% (HPLC)
 
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate




IDENTITY
CAS Number:52-01-7
MDL Number:MFCD00082250
MF:C24H32O4S
MW:416.57
EINECS:200-133-6
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:FT-IR, HPLC
Physical Form:White to light yellow powder or solid
Melting Point:198-208°C
Optical Rotation:-32 °--37 ° (c=1, CHCl3)
Long-Term Storage:Store at room temperature

REVIEW

 Spironolactone is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule. Aldosterone interacts with a cytoplasmic mineralocorticoid receptor to enhance the expression of the Na+, K+-ATPase and the Na+ channel involved in a Na+ K+ transport in the distal tubule . Spironolactone bind to this mineralcorticoid receptor, blocking the actions of aldosterone on gene expression. Aldosterone is a hormone; its primary function is to retain sodium and excrete potassium in the kidneys.

REFERENCES
[1]Berardesca E, Gabba P, Ucci G, Borroni G, Rabbiosi G: Topical spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris. Int J Tissue React. 1988;10(2):115-9.
[2] Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J: The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999 Sep 2;341(10):709-17.
[3] Wandelt-Freerksen E: [Aldactone in the treatment of sarcoidosis of the lungs (author's transl)] Z Erkr Atmungsorgane. 1977 Jul;149(1):156-9.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H360

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501


Current as of October 19, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.

WARNING: Attention California residents: This product can expose you to chemicals including Spironolactone, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES

 APIs and Bioactives > Diuretics, Antiandrogens


PubChem