106939-34-8 Levofloxacin Impurity 10 AKSci J10738
 
 
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  J10738    
Levofloxacin Impurity 10
, 98%, powder
 
Levofloxacin cyclized ester




IDENTITY
CAS Number:106939-34-8
MDL Number:MFCD09030626
MF:C15H13F2NO4
MW:309.26
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%, powder
Physical Form (at 20°C):Solid
Melting Point:262-263°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited.

REFERENCES
[1]Meggio, F., et al.: Biochemistry, 43, 12931 (2004)
[2] Traxler, P., et al.: J. Med. Chem., 42, 1018 (1999)
[3] Battistutta, R., et al.: J. Biol. Chem., 275, 29618 (2000)
[4] Bavi, R., et al.: Cancer Res., 62, 4180 (2000)

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 9, 2024


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CATEGORIES

 APIs and Bioactives > Antibacterials, Quinolones


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