[483-14-7] L-Tetrahydropalmatine AKSci J10724
 
 
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  J10724    
L-Tetrahydropalmatine
, 98% (HPLC)
 
Rotundine
Gindarine
(-)-Tetrahydropalmatine
more..




IDENTITY
CAS Number:[483-14-7]
MDL Number:MFCD03265591
MF:C21H25NO4
MW:355.43
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:NMR, LCMS, HPLC, Polarimetry
Physical Form:White to light yellow crystalline powder
Melting Point:118-124°C
Optical Rotation:-276° (c=0.8, EtOH)
Long-Term Storage:Store long-term at 2-8°C
UN #:Not hazmat

BIOLOGICAL INFO
Application(s):Voltage dependent L-type calcium channel inhibitor

REVIEW

 Tetrahydropalmatine is an racemic plant based alkaloid found in the Corydalis genus, and also in Stephania rotunda. These plants have traditional uses in Chinese herbal medicine. T he pharmaceutical industry has synthetically produced the more potent enantiomer Levo-tetrahydropalmatine (Levo-THP), which has been marketed worldwide under different brand names as an alternative to anxiolytic and sedative drugs of the benzodiazepine group and analgesics such as opiates. It is also sold as a dietary supplement. L-Tetrahydropalmatine has been shown to have analgesic effects and may be beneficial in the treatment of heart disease and liver damage. It is a blocker of voltage-activated L-type calcium channel active potassium channels. It is a potent muscle relaxant. It has also shown potential in the treatment of drug addiction to both cocaine and opiates, and preliminary human studies have shown promising results. Animal experiments have shown that the sedative effect of L- tetrahydropalmatine results from blocking dopaminergic neurons in the brain, in particular related to inhibition of D(2) dopamine receptors.. Dopamine is an important neurotransmitter in the central nervous system where it occurs in several important signaling systems that regulate muscular activity and attention, as well as feelings of joy, enthusiasm and creativity. Therefore, L-tetrahydropalmatine causes no feelings of euphoria, and has been seen as an alternative to addictive drugs for people suffering from anxiety and pain, and as a possibility for relief for people not helped by existing drugs.

REFERENCES
[1]Blanchfield, Joanne T.; Phytochemistry (Elsevier) 2003, V63(6), P711-720
[2] Sutin EL, Jacobowitz DM Neurochemicals in the dorsal pontine tegmentum. Prog Brain Res. 1991;88:3-14.
[3] Ma ZJ, Li XD, Gu XZ, Cheng LP, Mao SJ. Effects of different types and standard of processing vinegaron inherent constituents in rhizoma of Corydalis yanhusuo. Zhongguo Zhong Yao Za Zhi. 2006 Mar;31(6):465-7.
[4] Wu L, Ling H, Li L, Jiang L, He M. Beneficial effects of the extract from Corydalis yanhusuo in rats with heart failure following myocardial infarction. J Pharm Pharmacol. 2007 May;59(5):695-701.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of May 29, 2017


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CATEGORIES

 APIs and Bioactives > Alkaloids


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