132203-70-4 Cilnidipine AKSci J10716
 
 
Loading Please Wait...
  J10716    AKSci Reference Standard
Cilnidipine, 99% (HPLC), powder
 
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
FRC 8653
IDENTITY
CAS Number:132203-70-4
MDL Number:MFCD00865853
MF:C27H28N2O7
MW:492.52
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:105-110°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >=20mg/mL; H2O: 2mg/mL; EtOH: 15mg/mL
Application(s):Calcium channel blocker
Form:Free Base

REVIEW
 Cilnidipine is a dihydropyridine dual-type calcium channel blocker. It blocks L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply blood vessels.

REFERENCES
[1]Hirose, Takeshi; Suzuki, Hidehiko Cilnidipine for treatment of heart diseases Jpn. Kokai Tokkyo Koho (2000), JP 2000309535 A 20001107.
[2] L?hn M, Muzzulini U, Essin K, Tsang SY, Kirsch T, Litteral J, Waldron P, Conrad H, Klugbauer N, Hofmann F, Haller H, Luft FC, Huang Y, Gollasch M Cilnidipine is a novel slow-acting blocker of vascular L-type calcium channels that does not target protein kinase C. J Hypertens. 2002 May;20(5):885-93.
[3] Yamamoto Takashi; Niwa Seiji; Ohno Seiji; Onishi Tomoyuki; Matsueda Hiroyuki; Koganei Hajime; Uneyama Hisayuki; Fujita Shin-ichi; Takeda Tomoko; Kito Morikazu; et al Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels Bioorganic & medicinal chemistry letters (2006), 16(4), 798-802.
[4] Fukumoto S, Ishimura E, Motoyama K, Morioka T, Kimoto E, Wakikawa K, Shoji S, Koyama H, Shoji T, Emoto M, Nishizawa Y, Inaba M; Cilnidipine vs L-type calcium channel blockers Evaluation of Antihypertensive Renoprotective Effects in Diabetic patients (CLEARED) Study Investigators (2012). Antialbuminuric advantage of cilnidipine compared with L-type calcium channel blockers in type 2 diabetic patients with normoalbuminuria and microalbuminuria. Diabetes Res Clin Pract. 97(1):91-8. PMID 22336632.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H318

Precautionary Statements
P280; P305+P351+P338; P310

Current as of March 26, 2023

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS Request COA

⚠️
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.


CATEGORIES
 APIs and Bioactives > Calcium Channel Blockers


PubChem