132203-70-4 Cilnidipine AKSci J10716
 
 
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  J10716    
Cilnidipine, 99% (HPLC), powder
 
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
FRC 8653
IDENTITY
CAS Number:132203-70-4
MDL Number:MFCD00865853
MF:C27H28N2O7
MW:492.52
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:105-110°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >=20mg/mL; H2O: 2mg/mL; EtOH: 15mg/mL
Application(s):Calcium channel blocker
Form:Free Base

REVIEW
 Cilnidipine is a dihydropyridine dual-type calcium channel blocker. It blocks L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply blood vessels.

REFERENCES
[1]Hirose, Takeshi; Suzuki, Hidehiko Cilnidipine for treatment of heart diseases Jpn. Kokai Tokkyo Koho (2000), JP 2000309535 A 20001107.
[2] L?hn M, Muzzulini U, Essin K, Tsang SY, Kirsch T, Litteral J, Waldron P, Conrad H, Klugbauer N, Hofmann F, Haller H, Luft FC, Huang Y, Gollasch M Cilnidipine is a novel slow-acting blocker of vascular L-type calcium channels that does not target protein kinase C. J Hypertens. 2002 May;20(5):885-93.
[3] Yamamoto Takashi; Niwa Seiji; Ohno Seiji; Onishi Tomoyuki; Matsueda Hiroyuki; Koganei Hajime; Uneyama Hisayuki; Fujita Shin-ichi; Takeda Tomoko; Kito Morikazu; et al Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels Bioorganic & medicinal chemistry letters (2006), 16(4), 798-802.
[4] Fukumoto S, Ishimura E, Motoyama K, Morioka T, Kimoto E, Wakikawa K, Shoji S, Koyama H, Shoji T, Emoto M, Nishizawa Y, Inaba M; Cilnidipine vs L-type calcium channel blockers Evaluation of Antihypertensive Renoprotective Effects in Diabetic patients (CLEARED) Study Investigators (2012). Antialbuminuric advantage of cilnidipine compared with L-type calcium channel blockers in type 2 diabetic patients with normoalbuminuria and microalbuminuria. Diabetes Res Clin Pract. 97(1):91-8. PMID 22336632.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H318

Precautionary Statements
P280; P305+P351+P338; P310

Current as of November 21, 2024


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CATEGORIES
 APIs and Bioactives > Calcium Channel Blockers


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