72509-76-3 Felodipine AKSci J10715
 
 
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  J10715    AKSci Reference Standard
Felodipine
, >98% (HPLC)
 
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
Renedil
Feloday
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IDENTITY
CAS Number:72509-76-3
MDL Number:MFCD00868316
MF:C18H19Cl2NO4
MW:384.25
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Spectra:LCMS, HPLC
Physical Form:Yellow to yellow-green crystalline powder
Melting Point:142-146°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: 77mg/mL; H2O: <1mg/mL; EtOH: 72mg/mL
Application(s):Selective L-type Ca2+ channel blocker
Form:Free Base

REVIEW

 Felodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through voltage-gated L-type calcium channels. It reversibly competes against nitrendipine and other DHP CCBs for DHP binding sites in vascular smooth muscle and cultured rabbit atrial cells. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of felodipine result in an overall decrease in blood pressure. Felodipine may be used to treat mild to moderate essential hypertension.

REFERENCES
[1]Dunselman PH, Edgar B: Felodipine clinical pharmacokinetics. Clin Pharmacokinet. 1991 Dec;21(6):418-30.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of October 17, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Calcium Channel Blockers


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