378-44-9 Betamethasone AKSci J10710
 
 
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  J10710    AKSci Reference Standard
Betamethasone, 99% (HPLC)
 
Betadexamethasone
Flubenisolone
Rinderon
more..
IDENTITY
CAS Number:378-44-9
MDL Number:MFCD00062969
MF:C22H29FO5
MW:392.46
EINECS:206-825-4
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:255-258°C
Optical Rotation:+115° - +121° (c=1, Dioxane)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Water: 0.0063g/L (37°C)

REVIEW
 Betamethasone is glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. Betamethasone is a glucocorticoid receptor agonist.

REFERENCES
[1]Saraceno R, Gramiccia T, Frascione P, Chimenti S. Calcipotriene/betamethasone in the treatment of psoriasis: a review article. Expert Opin Pharmacother. (2009) Oct;10(14): 2357-65.
[2] Giardino G, Fusco A, Romano R, Gallo V, Maio F, Esposito T, Palamaro L, Parenti G, Salerno MC, Vajro P, Pignata C. Betamethasone therapy in ataxia telangiectasia: unraveling the rationale of this serendipitous observation on the basis of the pathogenesis. Eur J Neurol. (2013) May;20(5): 740-7.
[3] Basaran A, Basaran M, Sen C. Choice of glucocorticoid in HELLP syndrome - dexamethasone versus betamethasone: revisiting the dilemma. J Matern Fetal Neonatal Med. (2012) Dec;25(12): 2597-600.
[4] Taub, D.; Hoffsommer, R. D.; Slates, H. L.; Kuo, C. H.; Wendler, N. L.16beta-Methyl cortical steroids Journal of the American Chemical Society (1960), 82, 4012-26.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H360; H373

Precautionary Statements
P201; P202; P260; P281; P308+P313; P405; P501

Current as of January 30, 2025

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Steroid Hormones


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