REVIEW Econazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
REFERENCES
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Yan P, Li T, Bo M, Die L, Xing L (2011). Inhibition of bone resorption by econazole in rat osteoclast-like cells through suppressing TRPV5. Arch Pharm Res. 34(6):1007-13. PMID 21725822.
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Xia Y, Zhi X, Wang X, Chen M, Cheng J (2012). Ultrasound-enhanced surfactant-assisted dispersive liquid-liquid microextraction and high-performance liquid chromatography for determination of ketoconazole and econazole nitrate in human blood. Anal Bioanal Chem. 402(3):1241-7. PMID 22057719.
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