24169-02-6 Econazole nitrate AKSci J10707
 
 
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  J10707    AKSci Reference Standard
Econazole nitrate, >98% (HPLC), powder
 
1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole
Ecostatin
Econazole nitrate salt
IDENTITY
CAS Number:24169-02-6
MDL Number:MFCD00058160
MF:C18H16Cl3N3O4
MW:444.7
EINECS:246-053-5
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:163-167°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 89mg/mL; H2O: <1mg/mL; EtOH: 5mg/mL
Application(s):Antifungal Agent; 14-alpha Demethylase Inhibitor
Form:Nitrate

REVIEW
 Econazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

REFERENCES
[1]Yan P, Li T, Bo M, Die L, Xing L (2011). Inhibition of bone resorption by econazole in rat osteoclast-like cells through suppressing TRPV5. Arch Pharm Res. 34(6):1007-13. PMID 21725822.
[2] Xia Y, Zhi X, Wang X, Chen M, Cheng J (2012). Ultrasound-enhanced surfactant-assisted dispersive liquid-liquid microextraction and high-performance liquid chromatography for determination of ketoconazole and econazole nitrate in human blood. Anal Bioanal Chem. 402(3):1241-7. PMID 22057719.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H315; H319

Precautionary Statements
P261; P280; P305+P351+P338; P304+P340; P405; P501

Current as of October 15, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Fungicides


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