76824-35-6 Famotidine AKSci J10706
 
 
Loading Please Wait...
  J10706    
Famotidine
, >98% (HPLC), powder
 
N'-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine




IDENTITY
CAS Number:76824-35-6
MDL Number:MFCD00079297
MF:C8H15N7O2S3
MW:337.45
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:160-168°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Water 0.1mg/mL (ultrasonic), DMF 30 mg/ml, DMSO 30 mg/ml, Ethanol slightly soluble
Application(s):Histamine H2-receptor antagonist

REVIEW

 Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

REFERENCES
[1]Humphries TJ, Merritt GJ (August 1999). Review article: drug interactions with agents used to treat acid-related diseases. Aliment. Pharmacol. Ther. 13 Suppl 3: 18-26. doi:10.1046/j.1365-2036.1999.00021.x. PMID 10491725.
[2] Pali-Schöll I, Jensen-Jarolim E (April 2011). Anti-acid medication as a risk factor for food allergy. Allergy 66 (4): 469-77. doi:10.1111/j.1398-9995.2010.02511.x. PMID 21121928.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of November 13, 2024


Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

 APIs and Bioactives > Antihistamines


PubChem