REVIEW Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.
Humphries TJ, Merritt GJ (August 1999). Review article: drug interactions with agents used to treat acid-related diseases. Aliment. Pharmacol. Ther. 13 Suppl 3: 18-26. doi:10.1046/j.1365-2036.1999.00021.x. PMID 10491725.
Pali-Schöll I, Jensen-Jarolim E (April 2011). Anti-acid medication as a risk factor for food allergy. Allergy 66 (4): 469-77. doi:10.1111/j.1398-9995.2010.02511.x. PMID 21121928.
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