39562-70-4 Nitrendipine AKSci J10689

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J10689 AKSci Reference Standard
Nitrendipine, >98% (HPLC)

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester

BIOLOGICAL INFO
Solubility:	MeOH: 15mg/mL; DMSO: 17.5 mg/mL
Application(s):	Dihydropyridine calcium channel blocker

REVIEW
Nitrendipine is a racemic dihydropyridine calcium channel blocker for the treatment of primary hypertension.

REFERENCES

[1]	Meyer, Horst; Bossert, Friedrich; Vater, Wulf; Stoepel, Kurt Dialkyl 4-aryl-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylates Ger. Offen. (1972), DE 2117571 A 19721019.
[2]	Meyer, H.; Bossert, F.; Wehinger, E.; Stoepel, K.; Vater, W. Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical ester functions Arzneimittel-Forschung (1981), 31(3), 407-9.
[3]	Meyer, Horst; Bossert, Friedrich; Wehinger, Egbert; Scherling, Dietrich Chemistry of nitrendipine and its metabolites Edited by Scriabine, Alexander; Vanov, Svetislav; Deck, Klaus Nitrendipine (1984), 1-9.
[4]	Goa KL, Sorkin EM. Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension. Drugs. 1987 Feb;33(2):123-55.