39562-70-4 Nitrendipine AKSci J10689
 
 
Loading Please Wait...
  J10689    AKSci Reference Standard
Nitrendipine, >98% (HPLC)
 
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester
IDENTITY
CAS Number:39562-70-4
MDL Number:MFCD00082255
MF:C18H20N2O6
MW:360.36
EINECS:254-513-1
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Spectra:NMR, FT-IR, LCMS, HPLC
Physical Form:Yellow to green powder
Melting Point:158°C
Long-Term Storage:Store long-term at room temperature

BIOLOGICAL INFO
Solubility:MeOH: 15mg/mL; DMSO: 17.5 mg/mL
Application(s):Dihydropyridine calcium channel blocker

REVIEW
 Nitrendipine is a racemic dihydropyridine calcium channel blocker for the treatment of primary hypertension.

REFERENCES
[1]Meyer, Horst; Bossert, Friedrich; Vater, Wulf; Stoepel, Kurt Dialkyl 4-aryl-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylates Ger. Offen. (1972), DE 2117571 A 19721019.
[2] Meyer, H.; Bossert, F.; Wehinger, E.; Stoepel, K.; Vater, W. Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical ester functions Arzneimittel-Forschung (1981), 31(3), 407-9.
[3] Meyer, Horst; Bossert, Friedrich; Wehinger, Egbert; Scherling, Dietrich Chemistry of nitrendipine and its metabolites Edited by Scriabine, Alexander; Vanov, Svetislav; Deck, Klaus Nitrendipine (1984), 1-9.
[4] Goa KL, Sorkin EM. Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension. Drugs. 1987 Feb;33(2):123-55.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H312+H332

Precautionary Statements
P261; P271; P280; P302+P352; P304+P340; P312; P322; P363; P501

Current as of July 8, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.


CATEGORIES
 APIs and Bioactives > Calcium Channel Blockers


PubChem