6398-98-7 Amodiaquine dihydrochloride dihydrate AKSci J10682
 
 
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  J10682    AKSci Reference Standard
Amodiaquine dihydrochloride dihydrate
, >99% (HPLC)
 
4-(7-Chloro-4-quinolinylamino)-2-(diethylaminomethyl)phenol dihydrochloride dihydrate




IDENTITY
CAS Number:6398-98-7
MDL Number:MFCD09260307
MF:C20H22ClN3O.2HCl.2H2O
MW:464.82
EINECS:200-706-0
SPECIFICATIONS & PROPERTIES
Purity:>99% (HPLC)
Spectra:NMR, FT-IR, LCMS, HPLC
Physical Form:Yellow crystalline powder
Melting Point:165-172°C
Boiling Point:478°C
Flash Point:243°C
Long-Term Storage:Store at room temperature

REVIEW

 The mechanism of plasmodicidal action of amodiaquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites. The drug binds the free heme preventing the parasite from converting it to a form less toxic. This drug-heme complex is toxic and disrupts membrane function.

REFERENCES
[1]Jewell H, Maggs JL, Harrison AC, O'Neill PM, Ruscoe JE, Park BK: Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine. Xenobiotica. 1995 Feb;25(2):199-217.
[2] Harrison AC, Kitteringham NR, Clarke JB, Park BK: The mechanism of bioactivation and antigen formation of amodiaquine in the rat. Biochem Pharmacol. 1992 Apr 1;43(7):1421-30.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 18, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antimalarials


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