58-27-5 Menadione AKSci J10681
 
 
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  J10681    AKSci Reference Standard
Menadione
, 99% (GC)
 
2-Methylnaphthoquinone




IDENTITY
CAS Number:58-27-5
MDL Number:MFCD00001681
MF:C11H8O2
MW:172.18
EINECS:200-372-6
BRN:1908453
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (GC)
Physical Form (at 20°C):Solid
Melting Point:104-108°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Menadione is a synthetic chemical compound sometimes used as a nutritional supplement because of its vitamin K activity. It is an analog of 1,4-naphthoquinone with a methyl group in the 2-position, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. Menadione is used in the treatment of Hypoprothrombinemia outside of the United States.

REFERENCES
[1]Kidd Parris M. Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy. Alternative medicine review: a Journal of Clinical Therapeutic (2010) 15(3): 199-222.
[2] Kumagai, Yoshito; Shinkai, Yasuhiro; Miura, Takashi; Cho, Arthur K. The chemical biology of naphthoquinones and its environmental implications. Annual Review of Pharmacology and Toxicology. (2012) 52: 221-247.
[3] Lovern, Douglas; Marbois, Beth. Does menaquinone participate in brain astrocyte electron transport? Medical Hypotheses. (2013) 81(4): 587-591.
[4] Azizov, U. M.; Leont'eva, L. I.Methods for preparing 2-methyl-1,4-naphthoquinone (a review) Khimiko-Farmatsevticheskii Zhurnal (1989), 23(12), 1488-93.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of January 30, 2023

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Vitamins


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