REVIEW Menadione is a synthetic chemical compound sometimes used as a nutritional supplement because of its vitamin K activity. It is an analog of 1,4-naphthoquinone with a methyl group in the 2-position, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. Menadione is used in the treatment of Hypoprothrombinemia outside of the United States.
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Kumagai, Yoshito; Shinkai, Yasuhiro; Miura, Takashi; Cho, Arthur K. The chemical biology of naphthoquinones and its environmental implications. Annual Review of Pharmacology and Toxicology. (2012) 52: 221-247.
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Lovern, Douglas; Marbois, Beth. Does menaquinone participate in brain astrocyte electron transport? Medical Hypotheses. (2013) 81(4): 587-591.
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Azizov, U. M.; Leont'eva, L. I.Methods for preparing 2-methyl-1,4-naphthoquinone (a review) Khimiko-Farmatsevticheskii Zhurnal (1989), 23(12), 1488-93.
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