REVIEW Menadione is a synthetic chemical compound sometimes used as a nutritional supplement because of its vitamin K activity. It is an analog of 1,4-naphthoquinone with a methyl group in the 2-position, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. Menadione is used in the treatment of Hypoprothrombinemia outside of the United States.
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