5579-84-0 Betahistine dihydrochloride AKSci J10661
 
 
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  J10661    
Betahistine dihydrochloride, 99% (HPLC), powder
 
Methyl[2-(2-pyridyl)ethyl]amine dihydrochloride
IDENTITY
CAS Number:5579-84-0
MDL Number:MFCD00012813
MF:C8H14Cl2N2
MW:209.12
EINECS:226-966-5
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:150-155°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 38mg/mL; H2O: 38mg/mL; EtOH: 1mg/mL
Application(s):H1 Receptor Agonist; H3 Antagonist; Vasodilator Agent
Form:2HCl salt

REVIEW
 Betahistine dihydrochloride is an antivertigo drug first used for treating vertigo assosicated with Ménière's disease. It is also commonly used for patients with balance disorders, associated with Ménière's disease. Betahistine primarily acts as a histamine H1-agonist, stimulating the H1-receptors in the inner ear causes a vasodilatory effect and increased permeability in the blood vessels which results in reduced endolymphatic pressure.

REFERENCES
[1]Schmidt JT, Huizing EH. The clinical drug trial in Menière's disease with emphasis on the effect of betahistine SR. Acta Otolaryngol Suppl. (1992) 497: 1-189.
[2] Guth PS. The pharmacology of betahistine in the context of the vestibular system. Acta Otorhinolaryngol Ital. (2001) Jun;21(3 Suppl 66): 16-23.
[3] Lacour, Michel; van de Heyning, Paul H.; Novotny, Miroslav; Tighilet, Brahim. Betahistine in the treatment of Meniere's disease. Neuropsychiatric Disease and Treatment. (2007) 3(4): 429-440.
[4] Walter, L. A.; Hunt, Wm. H.; Fosbinder, Russell J. beta-(2- and 4-Pyridylalkyl)amines Journal of the American Chemical Society (1941), 63, 2771-3.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 13, 2025


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