REVIEW An antibiotic for treatment of Mycobacterium tuberculosis. Isoniazid is a prodrug that must be activated by a bacterial catalase-peroxidase enzyme, KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall.
REFERENCES
[1]
Forbes LV, Furtmüller PG, Khalilova I, Turner R, Obinger C, Kettle AJ (2012). Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation. Biochem Pharmacol. 84(7):949-60. PMID 22846601.
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