REVIEW A nonsteroidal anti-inflammatory drug (NSAIDs). NSAIDs work by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Etodolac blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.
Pareek A, Chandurkar N, Gupta A, Desai Y, Kumar S H, Swamy A, Sirsikar A (2011). Comparative evaluation of efficacy and safety of etodolac and diclofenac sodium injection in patients with postoperative orthopedic pain. Curr Med Res Opin. 27(11):2107-15. PMID 21942465.