60-56-0 Methimazole AKSci J10651
 
 
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  J10651    AKSci Reference Standard
Methimazole, 99% (HPLC), powder
 
1-Methyl-2-imidazolethiol, 2-Mercapto-1-methylimidazole
IDENTITY
CAS Number:60-56-0
MDL Number:MFCD00179321
MF:C4H6N2S
MW:114.17
EINECS:200-482-4
BRN:108646
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:142-146°C
Boiling Point:280°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Methimazole binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. So methimazole effectively inhibits the production of new thyroid hormones.

REFERENCES
[1]'Nakamura H, Noh JY, Itoh K, Fukata S, Miyauchi A, Hamada N (June 2007). Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves'' disease. The Journal of Clinical Endocrinology and Metabolism 92 (6): 2157-62. doi:10.1210/jc.2006-2135. PMID 17389704.'
[2] Crescioli C, Cosmi L, Borgogni E, et al. (October 2007). Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes. J. Endocrinol. 195 (1): 145-55. doi:10.1677/JOE-07-0240. PMID 17911406.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H317; H361

Precautionary Statements
P201; P202; P261; P272; P280; P302+P352; P308+P313; P321; P333+P313; P363; P405; P501

Current as of May 12, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Methimazole, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.




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