60-56-0 Methimazole AKSci J10651
 
 
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  J10651    AKSci Reference Standard
Methimazole
, 99% (HPLC), powder
 
1-Methyl-2-imidazolethiol, 2-Mercapto-1-methylimidazole




IDENTITY
CAS Number:60-56-0
MDL Number:MFCD00179321
MF:C4H6N2S
MW:114.17
EINECS:200-482-4
BRN:108646
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:142-146°C
Boiling Point:280°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Methimazole binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. So methimazole effectively inhibits the production of new thyroid hormones.

REFERENCES
[1]'Nakamura H, Noh JY, Itoh K, Fukata S, Miyauchi A, Hamada N (June 2007). Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves'' disease. The Journal of Clinical Endocrinology and Metabolism 92 (6): 2157-62. doi:10.1210/jc.2006-2135. PMID 17389704.'
[2] Crescioli C, Cosmi L, Borgogni E, et al. (October 2007). Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes. J. Endocrinol. 195 (1): 145-55. doi:10.1677/JOE-07-0240. PMID 17911406.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H317; H361

Precautionary Statements
P201; P202; P261; P272; P280; P302+P352; P308+P313; P321; P333+P313; P363; P405; P501


Current as of June 26, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.

WARNING: Attention California residents: This product can expose you to chemicals including Methimazole, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES

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