54029-12-8 Albendazole sulfoxide AKSci J10635
 
 
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  J10635    AKSci Reference Standard
Albendazole sulfoxide, >98% (HPLC), powder
 
Albendazole oxide
Methyl [5-(propane-1-sulfinyl)-1H-benzoimidazol-2-yl]-carbamate
Ricobendazole
IDENTITY
CAS Number:54029-12-8
MDL Number:MFCD00797922
MF:C12H15N3O3S
MW:281.33
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:226-233°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Assembly inhibitor

REVIEW
 Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

REFERENCES
[1]Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2). Merino G, Jonker JW Drug Metab. Dispos. 33, 614-618, (2005)
[2] Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: in vitro and in a xenograft model of peritoneal carcinomatosis. Pourgholami, M.H., et al. Cancer Chemother. Pharmacol. 55, 425-32, (2005)
[3] Molina AJ, Merino G, Prieto JG, Real R, Mendoza G, Alvarez AI: Absorption and metabolism of albendazole after intestinal ischemia/reperfusion. Eur J Pharm Sci. 2007 May;31(1):16-24. Epub 2007 Feb 6.
[4] Oxberry ME, Reynoldson JA, Thompson RC: The binding and distribution of albendazole and its principal metabolites in Giardia duodenalis. J Vet Pharmacol Ther. 2000 Jun;23(3):113-20.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

RELATED PRODUCTS
H152Albendazole
S313Albendazole oxide

Current as of April 26, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antiparasitics


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