[65-19-0] Yohimbine HCl AKSci J10623
 
 
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  J10623    AKSci Reference Standard
Yohimbine HCl
, 99% (HPLC)
 
17-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride




IDENTITY
CAS Number:[65-19-0]
MDL Number:MFCD00012674
MF:C21H26N2O3.HCl
MW:390.90
EINECS:200-600-4
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:273-301°C
Optical Rotation:+99° (c=1, H2O)
Long-Term Storage:Store at room temperature
UN #:UN1544
Hazard Class:6.1
Packing Group:II

BIOLOGICAL INFO
Solubility:H2O: 10mg/mL; Soluble to 25 mM in DMSO
Application(s):Sympatholytic agent

REVIEW

 Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated. However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei. Yohimbine-mediated norepinephrine release at the level of the corporeal tissues may also be involved. In addition, beneficial effects may involve other neurotransmitters such as dopamine and serotonin and cholinergic receptors.

REFERENCES
[1]Rosengren, A. H.; Jokubka, R.; Tojjar, D.; Granhall, C.; Hansson, O.; Li, D.-Q.; Nagaraj, V.; Reinbothe, T. M. et al. (2009). Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes. Science 327 (5962): 217-20. doi:10.1126/science.1176827. PMID 19965390.
[2] Saenz De Tejada, I; Kim, NN; Goldstein, I; Traish, AM (2000). Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum. International Journal of Impotence Research 12 Suppl 1: S20-25. doi:10.1038/sj.ijir.3900500. PMID 10845761.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H300; H311+H331

Precautionary Statements
P261; P264; P270; P271; P280; P301+P310; P302+P352; P304+P340; P312; P322; P330; P361; P363; P403+P233; P405; P501


Current as of February 23, 2017

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Alkaloids


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