61825-94-3 Oxaliplatin AKSci J10621
 
 
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  J10621    AKSci Reference Standard
Oxaliplatin, 99%, powder
 
(trans-1,2-Cyclohexanediamine)oxalatoplatinum(II)
IDENTITY
CAS Number:61825-94-3
MDL Number:MFCD00866327
MF:C10H22N2O4Pt
MW:397.29
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99%, powder
Physical Form (at 20°C):Solid
Melting Point:285-300°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 2mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):DNA Synthesis inhibitor
Form:Free Base

REVIEW
 A platinum-based antineoplastic agent that is used in cancer chemotherapy. Oxaliplatin functions by forming both inter- and intra- strand cross links in DNA. Cross links in DNA prevent DNA replication and transcription, resulting in cell death.

REFERENCES
[1]Margiotta N, Marzano C, Gandin V, Osella D, Ravera M, Gabano E, Platts JA, Petruzzella E, Hoeschele JD, Natile G (2012). Revisiting [PtCl2(cis-1,4-DACH)]: an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal cancer. J Med Chem. 55(16):7182-92. PMID 22788918.
[2] Pasetto LM, D'Andrea MR, Rossi E, Monfardini S: Oxaliplatin-related neurotoxicity: how and why? Crit Rev Oncol Hematol. 2006 Aug;59(2):159-68. Epub 2006 Jun 27.
[3] Graham J, Mushin M, Kirkpatrick P: Oxaliplatin. Nat Rev Drug Discov. 2004 Jan;3(1):11-2.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H317; H319; H335; H351

Precautionary Statements
P201; P202; P261; P264; P271; P272; P280; P302+P352; P304+P340; P305+P351+P338; P308+P313; P321; P333+P313; P337+P313; P362; P403+P233; P405; P501

Current as of June 28, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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