REVIEW Octopamine (beta, 4-dihydroxyphenethylamine) is an endogenous biogenic amine that is closely related to norepinephrine, and has effects on the adrenergic and dopaminergic systems. Octopamine HCl, a racemate, is an alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses.. Under the trade names Epirenor, Norden, and Norfen, octopamine is also used clinically as a sympathomimetic agent. It is also a neurotransmitter in some invertebrates.
REFERENCES
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Corrigan, John R.; Langerman, Marie-Jo; Moore, Maurice L. N-Substituted 1-(p-hydroxyphenyl)-2-aminoethanols. Journal of the American Chemical Society (1945), 67, 1894-6.
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Fujiwara, Motohatsu; Hattori, Keisuke; Mizusawa, Hideo; Muryobayashi, Takashi; Kato, Yoshiko Pharmacological action octopamine, with special reference to biochemical conversion to noradrenaline. Japanese Journal of Pharmacology (1968), 18(1), 113-29.
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Jagiello-Wójtowicz E. Mechanism of central action of octopamine. Pol J Pharmacol Pharm. 1979 Sep-Oct;31(5):509-16.
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