770-05-8 Octopamine HCl AKSci J10619
 
 
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  J10619    AKSci Reference Standard
Octopamine HCl
, 99%, powder
 
alpha-(Aminomethyl)-4-hydroxybenzyl alcohol hydrochloride
(±)-1-(4-Hydroxyphenyl)-2-aminoethanol hydrochloride




IDENTITY
CAS Number:770-05-8
MDL Number:MFCD00012881
MF:C8H12ClNO2
MW:189.64
SPECIFICATIONS & PROPERTIES
Purity:99%, powder
Physical Form:Crystals
Melting Point:169-171°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:H2O: soluble
Form:HCl salt

REVIEW

 Octopamine (beta, 4-dihydroxyphenethylamine) is an endogenous biogenic amine that is closely related to norepinephrine, and has effects on the adrenergic and dopaminergic systems. Octopamine HCl, a racemate, is an alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses.. Under the trade names Epirenor, Norden, and Norfen, octopamine is also used clinically as a sympathomimetic agent. It is also a neurotransmitter in some invertebrates.

REFERENCES
[1]Mannich, C.; Thiele, E. beta-Hydroxy-beta-phenylethylamine and related compounds. Archiv der Pharmazie (Weinheim, Germany) (1915), 253, 181-95.
[2] Corrigan, John R.; Langerman, Marie-Jo; Moore, Maurice L. N-Substituted 1-(p-hydroxyphenyl)-2-aminoethanols. Journal of the American Chemical Society (1945), 67, 1894-6.
[3] Fujiwara, Motohatsu; Hattori, Keisuke; Mizusawa, Hideo; Muryobayashi, Takashi; Kato, Yoshiko Pharmacological action octopamine, with special reference to biochemical conversion to noradrenaline. Japanese Journal of Pharmacology (1968), 18(1), 113-29.
[4] Jagiello-Wójtowicz E. Mechanism of central action of octopamine. Pol J Pharmacol Pharm. 1979 Sep-Oct;31(5):509-16.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302+H312+H332

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P312; P322; P330; P363; P501


Current as of July 2, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Adrenergic Agonists


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