103628-48-4 Sumatriptan succinate AKSci J10615
 
 
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  J10615    AKSci Reference Standard
Sumatriptan succinate
, >98% (HPLC), powder
 
Imigran
Imitrex, Suminat
Sumitrex
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IDENTITY
CAS Number:103628-48-4
MDL Number:MFCD00902856
MF:C18H27N3O6S
MW:413.49
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:163-172°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O: >20mg/mL
Application(s):5-HT agonist
Form:Succinate

REVIEW

 The 5-HT1B and 5-HT1D receptors function as autoreceptors, which inhibit the firing of serotonin neurons and a reduction in the synthesis and release of serotonin upon activation. After sumatriptan binds to these receptors, adenylate cyclase activity is inhibited via regulatory G proteins, incrases intracellular calcium, and affects other intracellular events. This results in vasoconstriction and inhibtion of sensory nociceptive (trigeminal) nerve firing and vasoactive neuropeptide release.

REFERENCES
[1]Nikai T, Basbaum AI, Ahn AH: Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan. Pain. 2008 Oct 31;139(3):533-40. Epub 2008 Aug 23.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H318

Precautionary Statements
P280; P305+P351+P338; P310


Current as of February 7, 2023

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Serotonin Agonists


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