943-17-9 Etilefrine HCl AKSci J10600
 
 
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  J10600    
Etilefrine HCl, 99% (HPLC), powder
 
3-[2-(Ethylamino)-1-hydroxyethyl]phenol hydrochloride
2-Ethylamino-1-(3-hydroxyphenyl)ethanol hydrochloride
IDENTITY
CAS Number:943-17-9
MDL Number:MFCD00060167
MF:C10H16ClNO2
MW:217.69
EINECS:213-398-8
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:122-128°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O
Application(s):Adrenergic alpha-Agonist; Adrenergic beta-1 Receptor Agonist
Form:HCl salt

REVIEW
 Etilefrine is a cardiac stimulant used as an antihypotensive. It is a sympathomimetic amine of the 3-hydroxy-phenylethanolamine series used in treating orthostatic hypotension of neurological, cardiovascular, endocrine or metabolic origin. Intravenous infusion of this compound increases cardiac output, stroke volume, venous return and blood pressure in man and experimental animals, suggesting stimulation of both alpha and beta adrenergic receptors.

REFERENCES
[1]Frost, B. R.; Frewin, D. B.; Gerke, D. C. The effects of etilefrine on blood vessels in the rat tail. Journal of Pharmacy and Pharmacology. (1977) 29(5): 272-5.
[2] Westermann, K. W.; Roehrs, M. Hemodynamic effects of etilefrine-dose-effect reactions to intraarterial and intravenous administration before and after alpha- and beta-sympatholytics. Herz/Kreislauf. (1980) 12(10): 442-52.
[3] Hahn, N.; Malotki, D.; Raque, B.; Brandsch, R.; Schumacher, G.; Felix, R. Experimental investigations on the effects of Etilefrine hydrochloride (Effortil) on the heart and circulation of animals with partial ischemic damage of the myocardium. Zeitschrift fuer Kardiologie. (1980) 69(11): 771-8.
[4] Goto, Toshio Preparation of some 1-(m-hydroxyphenyl)-2-alkylamino-ethanols Yakugaku Zasshi (1954), 74, 318-19

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024


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