14113-05-4 10-HDA AKSci J10599
 
 
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  J10599    
10-HDA, >98% (GC)
 
Royal Jelly acid
(E)-10-Hydroxy-2-decenoic acid
10-hydroxy-2-decenoic acid
more..
IDENTITY
CAS Number:14113-05-4
MDL Number:MFCD00204506
MF:C10H18O3
MW:186.25
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (GC)
Physical Form (at 20°C):Solid
Melting Point:61-65°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in chloroform, ethanol, methanol
Application(s):An inhibitor of VEGF-induced angiogenesis, cell migration and proliferation

REVIEW
 10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 µM. It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 µM. 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 µM and 1.5 mM, respectively.

REFERENCES
[1]Kodai, T., Umebayashi, K., Nakatani, T., et al. Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera). Chem Pharm Bull 55(10) 1528-1531 (2007).
[2] Honda, Y., Fujita, Y., Maruyama, H., et al. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS One 6(8) 1-10 (2011).
[3] Wang, J., Ruan, J., Li, C., et al. Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis. Rheumatol Int (2011).
[4] Wang, J., Ruan, J., Li, C., et al. Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis. Rheumatol Int (2011).

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 20, 2024


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CATEGORIES
 APIs and Bioactives > Natural Products


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