120511-73-1 Anastrozole AKSci J10596
 
 
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  J10596    AKSci Reference Standard
Anastrozole, 99% (HPLC), powder
 
2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1, 3-phenylene]bis(2-methyl-propiononitrile
Arimidex
a,a,a',a'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
IDENTITY
CAS Number:120511-73-1
MDL Number:MFCD00866298
MF:C17H19N5
MW:293.37
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC), powder
Spectra:NMR, FT-IR, GCMS, GC
Physical Form:White to off-white crystalline powder
Melting Point:80-86°C
Flash Point:238°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: 40mg/mL; H2O: <1mg/mL; EtOH: 59mg/mL
Application(s):Aromatase inhibitor
Form:Free Base

REVIEW
 Anastrozole selectively inhibits aromatase. The principal source of circulating estrogen (primarily estradiol) is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues. Therefore, aromatase inhibition leads to a decrease in serum and tumor concentration of estrogen, leading to a decreased tumor mass or delayed progression of tumor growth in some women. Anastrozole has no detectable effect on synthesis of adrenal corticosteroids, aldosterone, and thyroid hormone.

REFERENCES
[1]Howell A, Cuzick J, Baum M, Buzdar A, Dowsett M, Forbes JF, Hoctin-Boes G, Houghton J, Locker GY, Tobias JS: Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet. 2005 Jan 1-7;365(9453):60-2.
[2] Mauras N, Bishop K, Merinbaum D, Emeribe U, Agbo F, Lowe E: Pharmacokinetics and pharmacodynamics of anastrozole in pubertal boys with recent-onset gynecomastia. J Clin Endocrinol Metab. 2009 Aug;94(8):2975-8. Epub 2009 May 26.
[3] Nabholtz JM: Role of anastrozole across the breast cancer continuum: from advanced to early disease and prevention. Oncology. 2006;70(1):1-12. Epub 2006 Jan 26.
[4] Milani M, Jha G, Potter DA: Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women. Clin Med Ther. 2009 Mar 31;1:141-156.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H302; H360

Precautionary Statements
P201; P202; P264; P270; P281; P301+P312; P308+P313; P330; P405; P501

Current as of July 6, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Aromatose inhibitors


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