78755-81-4 Flumazenil AKSci J10590
 
 
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  J10590    AKSci Reference Standard
Flumazenil, 99% (HPLC), powder
 
Ro 15-1788
4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
Flumazepil
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IDENTITY
CAS Number:78755-81-4
MDL Number:MFCD00242764
MF:C15H14FN3O3
MW:303.29
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:198-203°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 5mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Benzodiazepine receptor antagonist; GABA antagonist
Form:Free base

REVIEW
 Flumazenil is an imidazobenzodiazepine derivative, which antagonizes the actions of benzodiazepines on the central nervous system. It is used for the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, and where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures.

REFERENCES
[1]Whitwam, J. G.; Amrein, R. Pharmacology of flumazenil. Acta Anaesthesiologica Scandinavica, Supplementum. (1995) 108: 3-14.
[2] Boccuzzi-Chmura L; Robertson D C. Flumazenil (romazicon) and the patient with benzodiazepine overdose: risks versus benefits. Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association. (1996) 22(4): 330-3
[3] Bentue-Ferrer, D.; Bureau, M.; Patat, A.; Allain, H. Flumazenil. CNS Drug Reviews. (1997) Volume Date1996, 2(4): 390-414.
[4] Mohler, Hanns; Hunkeler, Walter; Polc, Petar; Haefely, Willy; Pieri, Lorenzo; Kyburz, Emilio; Gerecke, Max Imidazodiazepine derivatives and their use as drugs Braz. Pedido PI (1981), BR 8006404 A 1981041

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 20, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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