105826-92-4 Tropisetron HCl AKSci J10574
 
 
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  J10574    AKSci Reference Standard
Tropisetron HCl
, 99% (HPLC)
 
1H-Indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester monohydrochloride
3-Tropanylindole-3-carboxylate monohydrochloride
Navoban




IDENTITY
CAS Number:105826-92-4
MDL Number:MFCD02313825
MF:C17H20N2O2.HCl
MW:320.81
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:LCMS, FT-IR, HPLC
Physical Form:White crystals
Melting Point:283-285°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:DMSO: 35mg/mL; H2O: 64mg/mL; EtOH: <1mg/mL
Application(s):Selective 5-HT3 receptor antagonist and alpha-7-nicotinic receptor agonist
Form:HCl salt

REVIEW

 Tropisetron is a highly potent and selective competitive antagonist of the 5-HT3 receptor, a subclass of serotonin receptors located on peripheral neurons and within the CNS. Surgery and treatment with certain substances, including some chemotherapeutic agents, may trigger the release of serotonin (5-HT) from enterochromaffin-like cells in the visceral mucosa and initiate the emesis reflex and its accompanying feeling of nausea. Tropisetron selectively blocks the excitation of the presynaptic 5-HT3 receptors of the peripheral neurons in this reflex, and may exert additional direct actions within the CNS on 5-HT3 receptors mediating the actions of vagal input to the area postrema.

REFERENCES
[1]Muller, W.; T. Stratz (2004). Local treatment of tendinopathies and myofascial pain syndromes with the 5-HT3 receptor antagonist tropisetron. Scand J Rheumatic Suppl. 119 (119): 44-48. PMID 15515413. Retrieved 2007-05-17.
[2] Macor JE, Gurley D, Lanthorn T, Loch J, Mack RA, Mullen G, Tran O, Wright N, Gordon JC (February 2001). The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist. Bioorganic & Medicinal Chemistry Letters 11 (3): 319-21. doi:10.1016/S0960-894X(00)00670-3. PMID 11212100.
[3] Cui R, Suemaru K, Li B, Kohnomi S, Araki H (May 2009). Tropisetron attenuates naloxone-induced place aversion in single-dose morphine-treated rats: role of alpha7 nicotinic receptors. European Journal of Pharmacology 609 (1-3): 74-7. doi:10.1016/j.ejphar.2008.12.051. PMID 19374878.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 2, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Serotonin Antagonists


PubChem