651-06-9 Sulfameter AKSci J10570
 
 
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  J10570    AKSci Reference Standard
Sulfameter
, 98% (HPLC)
 
Sulphanilamide p-methoxy pyrimidine




IDENTITY
CAS Number:651-06-9
MDL Number:MFCD00006067
MF:C11H12N4O3S
MW:280.3
EINECS:211-480-8
BRN:621130
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:213-215°C
Density:1.465
Refractive Index:1.647
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Sulfametoxydiazine or sulfamethoxydiazine (sulfameter) is a long-acting sulfonamide antibacterial, encompassing most gram-positive and many gram-negative organisms. It is used as a leprostatic agent and in the treatment of urinary tract infections. Sulfameter and all sulfonamide anitbacterials are antimetabolites, whereby the sulfonamidecompete with para-aminobenzoic acid (PABA) for incorporation into folic acid. The action of sulfonamides illustrates the principle of selective toxicity where some difference between mammal cells and bacterial cells is exploited. All cells require folic acid for growth. Folic acid (as a vitamin is in food) diffuses or is transported into human cells. However, folic acid cannot cross bacterial cell walls by diffusion or active transport. For this reason bacteria must synthesize folic acid from p-aminobenzoic acid.

REFERENCES
[1]Bass, Allan D.; Weinstein, Ira Chemotherapy of bacterial infections. II. Sulfonamides , Edited by DiPalma, Joseph R , Drill's Pharmacol. Med., 4th Ed. (1971), 1657-73.
[2] Sammes, Peter G. Sulfonamides and sulfones Edited by Hansch, Corwin; Sammes, Peter G.; Taylor, John B, Comprehensive Medicinal Chemistry (1990), 2, 255-270.
[3] Budesinsky, Z.; Bydzovsky, V.; Prikryl, J.; Svab, J. Sulfonamides with protracted antibacterial activity. I. 2-Sulfanilamidoalkoxypyrimidines Cesko-Slovenska Farmacie (1961), 10, 14-20.
[4] Horstmann, H.; Knott, Th.; Scholtan, W.; Schraufstaetter, E.; Walter, A.; Woerffel, U Relations between structure activity and protein binding in the 2-sulfanilamidopyrimidine series Arzneimittel-Forschung (1961), 11, 682-4.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 16, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antibacterials


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