497-76-7 Arbutin AKSci J10569
 
 
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  J10569    AKSci Reference Standard
Arbutin, >98% (HPLC)
 
4-Hydroxyphenyl-beta-D-glucopyranoside, p-Arbutin, Hydroquinone beta-D-glucopyranoside
IDENTITY
CAS Number:497-76-7
MDL Number:MFCD00016915
MF:C12H16O7
MW:272.25
EINECS:207-850-3
BRN:89673
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Spectra:NMR, FT-IR, LCMS, HPLC, Polarimetry
Physical Form:White to off-white powder
Melting Point:196-202°C
Optical Rotation:-65° (c=2, H2O)
Long-Term Storage:Store at room temperature
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Tyrosinase inhibitor

REVIEW
 Arbutin is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos that is used as a skin-lightening agent. It inhibits tyrosinase and thus prevents the formation of melanin.

REFERENCES
[1]Tan, Hiroaki; Isayama, Shigeru A process for the preparation of arbutin and analogs as drugs Jpn. Kokai Tokkyo Koho (1987), JP 62226974 A 19871005.
[2] Huang, Shen-lin; Zhu, Yu-lin; Pan, Yuan-jiang; Wu, Shi-hua Synthesis of arbutin by two-step reaction from glucose Journal of Zhejiang University, Science (2004), 5(12), 1509-1511.
[3] Cepanec, Ivica; Litvic, Mladen Simple and efficient synthesis of arbutin ARKIVOC (Gainesville, FL, United States) (2008), (2), 19-24.
[4] Carmen Pop, Laurian Vlase, Mircea Tamas, Natural Resources Containing Arbutin. Determination of Arbutin in the Leaves of Bergenia crassifolia (L.) Fritsch. acclimated in Romania. Not. Bot. Hort. Agrobot. Cluj 2009, 37 (1): 129-132.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of July 23, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Dermatology
 Carbohydrates > Glycosides, Monosaccharides
 Carbohydrates > Glycosides, Monosaccharides


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