REVIEW Arbutin is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos that is used as a skin-lightening agent. It inhibits tyrosinase and thus prevents the formation of melanin.
Tan, Hiroaki; Isayama, Shigeru A process for the preparation of arbutin and analogs as drugs Jpn. Kokai Tokkyo Koho (1987), JP 62226974 A 19871005.
Huang, Shen-lin; Zhu, Yu-lin; Pan, Yuan-jiang; Wu, Shi-hua Synthesis of arbutin by two-step reaction from glucose Journal of Zhejiang University, Science (2004), 5(12), 1509-1511.
Cepanec, Ivica; Litvic, Mladen Simple and efficient synthesis of arbutin ARKIVOC (Gainesville, FL, United States) (2008), (2), 19-24.
Carmen Pop, Laurian Vlase, Mircea Tamas, Natural Resources Containing Arbutin. Determination of Arbutin in the Leaves of Bergenia crassifolia (L.) Fritsch. acclimated in Romania. Not. Bot. Hort. Agrobot. Cluj 2009, 37 (1): 129-132.
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