1405-20-5 Polymyxin B sulfate, >6500IU/mg AKSci J10554
 
 
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  J10554    AKSci Reference Standard
Polymyxin B sulfate, >6500IU/mg
 
Polymyxin B sulphate
Aerosporin
IDENTITY
CAS Number:1405-20-5
MDL Number:MFCD00131991
MF:C55H96N16O13.2H2SO4
MW:1385.61
EINECS:215-774-7
SPECIFICATIONS & PROPERTIES
Physical Form (at 20°C):Solid
Melting Point:233-243°C
Optical Rotation:-78.0° ~ -82.0° (c=2, H2O)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O: soluble 50mg/mL (Stock solutions should be filter sterilized and stored at 2-8 °C. Stable at 37 °C for 5 days.)

REVIEW
 Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipopolysaccharide of the cytoplasmic outer membrane of Gram-negative bacteria, altering membrane permeability and causing cell death. It does not need to enter the cell.

REFERENCES
[1]Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8.
[2] Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of April 25, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antibacterials, Polymyxins


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