5786-21-0 Clozapine AKSci J10544
 
 
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  J10544    
Clozapine
, 99% (HPLC)
 
Leponex
Fazaclo
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine




IDENTITY
CAS Number:5786-21-0
MDL Number:MFCD00153785
MF:C18H19ClN4
MW:326.82
EINECS:227-313-7
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:LCMS, FT-IR, HPLC
Physical Form:Yellow crystalline powder
Melting Point:180-187°C
Long-Term Storage:Store at room temperature
UN #:UN2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Solubility:DMSO: 4.8mg/mL; H2O: <1mg/mL; EtOH: 1mg/mL
Application(s):5-HT1C receptor antagonist; selective D4-dopamine receptor antagonist
Form:Free Base
Research Area:Originator: Novartis

REFERENCES
[1]Mc Fie S, Sterley TL, Howells FM, Russell VA (2012). Clozapine decreases exploratory activity and increases anxiety-like behaviour in the Wistar-Kyoto rat but not the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Brain Res. 1467:91-103. PMID 22658977.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301; H341; H351; H361

Precautionary Statements
P201; P202; P264; P270; P281; P301+P310; P308+P313; P321; P330; P405; P501


Current as of January 18, 2019


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CATEGORIES

 APIs and Bioactives > Antipsychotics, Serotonin Agonists


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