68373-14-8 Sulbactam AKSci J10526
 
 
Loading Please Wait...
  J10526    AKSci Reference Standard
Sulbactam
, >98% (HPLC)
 
(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid 4,4-Dioxide
Betamaze
Penicillanic acid 1,1-dioxide
more..




IDENTITY
CAS Number:68373-14-8
MDL Number:MFCD00867005
MF:C8H11NO5S
MW:233.24
EINECS:269-878-2
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Spectra:NMR, LCMS, HPLC, polarimetry
Physical Form:White to orange crystalline powder
Melting Point:150-157°C
Optical Rotation:+233.0° - +241.0° (c=1, H2O)
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:H2O: .18mg/mL
Application(s):beta-Lactamase inhibitor

REVIEW

 Sulbactam free acid is a beta-lactamase inhibitor with very weak antibacterial action. This drug is given in combination with beta-lactam antibiotics to prevent destruction of the beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone. Sulbactam is an irreversible inhibitor of beta-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic. The actual drug given to patients is the sodium salt of sulbactam.

REFERENCES
[1]Barth, Wayne Ernest; Penicillanic acid 1,1-dioxides Ger. Offen. (1978), DE 2824535 A1 19781214.
[2] Barth, Wayne E. Penicillanic acid 1,1-dioxides as betalactamase inhibitors U.S. (1980), US 4234579 A 19801118.
[3] Sjövall J, Huitfeldt B, Magni L, Nord CE. Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73-84.
[4] Foulds G. Pharmacokinetics of sulbactam/ampicillin in humans: a review. Rev Infect Dis. 1986 Nov-Dec;8 Suppl 5:S503-11.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of October 22, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Antibacterials


PubChem
  @PubMed