REVIEW An oral rapid- and short-acting anti-diabetic drug from the sulfonylurea class. Glipizide blocks potassium channels in the beta cells of the islets of Langerhans. By partially blocking the potassium channels, the cell remains depolarized, increasing the time the cell spends in the calcium release stage of cell, which results in signaling leading to calcium influx. The increase in calcium will initiate more insulin release from each beta cell.
REFERENCES
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Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W (2011). Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 7(12):e1002310. PMID 22194678.
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