1263-89-4 Paromomycin sulfate, ≥675 mcg/mg (Assay, anhydrous basis) AKSci J10521
 
 
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  J10521    
Paromomycin sulfate, ≥675 mcg/mg (Assay, anhydrous basis)
 



IDENTITY
CAS Number:1263-89-4
MDL Number:MFCD00079278
MF:C23H45N5O14.H2SO4
MW:713.71
EINECS:215-031-7
SPECIFICATIONS & PROPERTIES
Physical Form (at 20°C):Solid
Melting Point:>360°C
Optical Rotation:+51° (c=5, water)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O: 50mg/mL

REVIEW

 Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.

REFERENCES
[1]Vicens Q, Westhof E: Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site. Structure. 2001 Aug;9(8):647-58.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 13, 2024


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CATEGORIES

 APIs and Bioactives > Antibacterials, Aminoglycosides


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