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BIOLOGICAL INFO
Solubility:
H2O: soluble20 mg/mL, clear
Application(s):
Tertiary amine
Form:
HCl salt
REVIEW Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: pain, temperature, touch, proprioception, and skeletal muscle tone.
REFERENCES
[1]
Porto GG, Vasconcelos BC, Gomes AC, Albert D (January 2007). Evaluation of lidocaine and mepivacaine for inferior third molar surgery. Med Oral Patol Oral Cir Bucal 12 (1): E60-4. PMID 17195831.
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